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KMID : 0043320150380081541
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Archives of Pharmacal Research
2015 Volume.38 No. 8 p.1541 ~ p.1551
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Triterpene glycosides with stimulatory activity on melanogenesis from the aerial parts of Weigela subsessilis
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Won Yu-Mi
Seong Zuh-Kyung
Kim Jae-Lim
Kim Hui-Seong
Song Hyuk-Hwan
Kim Doo-Young
Kim Jung-Hee
Oh Sei-Ryang
Cho Hyun-Woo
Cho Jung-Hee
Lee Hyeong-Kyu
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Abstract
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Three new triterpene glycosides (Lonicerosides K, L and M) and 11 known compounds were isolated from the aerial parts of Weigela subsessilis. Among the known isolated compounds, loniceroside A, sweroside, kaempferol-3-O-glucopyranoside 6″-(3-hydroxy-3-methylglutarate), kaempferol-3-O-acetylglucoside and grandifloroside were reported for the first time in a Weigela genus plant. Their chemical structures were identified using extensive spectroscopic analysis including two-dimensional (2D)-NMR experiments, HR-ESI-QTOF-MS and comparison with reported data. Among these compounds, lonicerosides A and L had potent melanogenesis stimulatory activity in murine B16F0 melanoma cells. The structural relationship of active compounds was discussed.
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KEYWORD
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Weigela subsessilis, Caprifoliaceae, Melanogenesis stimulatory activity, Triterpene glycoside, Lonicerosides K?M
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